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Cardiovascular Protection: GLP-1s are proven to lower blood pressure and improve cholesterol levels
Survodutide (Boehringer Ingelheim/Zealand) is a GLP-1/glucagon dual agonist showing about 19% in Phase 2 and now in Phase 3
Gastrointestinal AE with cagrisema were more than with semagutide or cagrilintide monotherapy, however the SAE and AE leading to medication discontinuation were minimal and similar between the groups [87, 90] A programme of phase 3 clinical trials (REDEFINE) assessing the safety and efficacy of cagrisema in people with obesity (NCT05567796, NCT05394519, NCT05813925) is currently ongoing
Leave-one-out analyses indicated that results were largely driven by single-study influence, reflecting the limited evidence base (Fig
A 1992 study by Anisimov et al
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